Seroepidemiology of Hantaan-related virus in Gabon.
نویسندگان
چکیده
Haemorrhagic fever with renal syndrome (HFRS) has been described m a i n l y Y n í E i m Europe. Serological evidence of infection by Hantaan or a related virus has more recently been reported in Africa: in Gabon, only one of 30 sera examined was positive (GONZALEZ et al., 1984). In Senegal, SALUZ20 et al. (1985) reported a prevalence of 16.5% in inhabitants of Kabrousse, with 31% of tested rats seropositive. We have conducted an epidemiological survey in a village in the Province of Haut-Ogooue (south-east Gabon). We examined 213 people (80% of the population) and obtained blood samples. Antibodies to Hantaan virus were tested for by an indirect immunofluorescent assay, using as antigen Vero E6 cells infected with strain 76-118 of Hantaan virus (GONZALEZ et al., 1984). Of the 213 sera tested, 17 (8%) were positive with IgG titres between 1 in 16 and 1 in 128. IgM antibodies, at titres of 1 in 16 to 1 in 32, were found in 4 of the IgG positive sera but none of the IgG negative sera. The age range of individuals with positive serology was 4 to 70 years. No sex difference was observed. No symptom of haemorrhagic or rena1 disease was noted. Urine examination, using semiquantitative strips, showed only 2 cases of low proteinuria (0*30g/l) and one of haematuria (>500 RBC/pI). None of the 4 people with IgM antibodies had urine abnormalities. Creatinine levels were high 519
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ورودعنوان ژورنال:
- Transactions of the Royal Society of Tropical Medicine and Hygiene
دوره 81 3 شماره
صفحات -
تاریخ انتشار 1987